In an anaphylactic reaction, which drug and dose is recommended according to the protocol?

• A. Glucagon 1 mg IM
• B. Adrenaline 0.5 mg IM
• C. Aspirin 300 mg PO
• D. Glyceryl Trinitrate spray 2 puffs

Answer: (B)

In anaphylaxis, adrenaline given by intramuscular injection is the first-line treatment because it rapidly counters the life-threatening symptoms by squeezing blood vessels to raise blood pressure and reduce swelling, while also relaxing airway smooth muscle to improve breathing. The recommended dose for an adult is 0.5 mg injected into the mid-outer thigh, and this can be repeated every 5–15 minutes if symptoms persist or worsen, with urgent medical help sought immediately. The other options don’t address the key problems seen in anaphylaxis: glucagon is not a standard first-line treatment for this situation (it's used for certain hypoglycemic states or specific drug interactions), aspirin is irrelevant to reversing anaphylaxis and can worsen bleeding risk, and a glyceryl trinitrate spray isn't appropriate as it can lower blood pressure and does not treat airway obstruction or bronchospasm. Using adrenaline promptly targets the underlying pathophysiology, making it the best choice in this protocol.